Structure and function of an N-acetyltransferase from the human pathogen Acinetobacter baumannii isolate BAL_212.

ABSTRACT: Acinetobacter baumannii is a Gram-negative bacterium commonly found in soil and water that can cause human infections of the blood, lungs, and urinary tract. Of particular concern is its prevalence in health-care settings where it can survive on surfaces and shared equipment for extended periods of time. The capsular polysaccharide surrounding the organism is known to be the major contributor to virulence. The structure of the K57 capsular polysaccharide produced by A. baumannii isolate BAL_212 from Vietnam was recently shown to contain the rare sugar 4-acetamido-4,6-dideoxy-d-glucose. Three enzymes are required for its biosynthesis, one of which is encoded by the gene H6W49_RS17300 and referred to as VioB, a putative N-acetyltransferase. Here, we describe a combined structural and functio

SUBMITTER: Herkert NR 

PROVIDER: S-EPMC9271549 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature