Endogenous sex hormones, aromatase activity and lung cancer risk in postmenopausal never-smoking women.

ABSTRACT: Although reproductive factors have been repeatedly associated with lung cancer risk, no study to date has directly evaluated the relationship with endogenous sex hormones nor with aromatase activity in postmenopausal never-smoking women. A case-control study of 397 incident lung cancer cases and their individually matched controls, nested within the Shanghai Women's Health Study, was conducted among postmenopausal women who were lifetime never smokers. Prediagnostic concentrations of sex hormones was quantitated using LC-MS/MS assays in plasma. The product-substrate molar ratio of estrone to androstenedione was used as an index of aromatase activity (IAA). Multivariable conditional logistic regression models were used to calculate odds ratios (ORs) for lung cancer. Baseline concentrations

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC9271581 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature