Effectiveness and Safety of JAK Inhibitors in Autoinflammatory Diseases: A Systematic Review.

ABSTRACT:

Introduction

Autoinflammatory diseases (AID) are rare diseases presenting with episodes of sterile inflammation. These involve multiple organs and can cause both acute organ damage and serious long-term effects, like amyloidosis. Disease-specific anti-inflammatory therapeutic strategies are established for some AID. However, their clinical course frequently includes relapsing, uncontrolled conditions. Therefore, new therapeutic approaches are needed. Janus Kinase inhibitors (JAKi) block key cytokines of AID pathogenesis and can be a potential option.

Methods

A systematic review of the literature in accordance with the PRISMA guidelines was conducted. Three databases (MEDLINE, Embase and Cochrane Central Register of Controlled Trials) were searched for publications regarding

SUBMITTER: Boyadzhieva Z 

PROVIDER: S-EPMC9271622 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature