Patients With Multiple Myeloma Have a Disbalanced Whole Blood Thrombin Generation Profile.

ABSTRACT:

Background

Multiple myeloma (MM) is associated with a high prevalence of bleeding and an increased risk of thrombo-embolism. MM patients have reduced platelet- and red blood cell (RBC) numbers in blood, which may indicate that the paradoxical hemostasis profile is a consequence of a disturbed platelet and RBC homeostasis.

Objectives

To get better insight in the disbalanced hemostasis of MM patients.

Methods

We conducted a case-control study on the whole blood (WB) coagulation profiles of 21 MM patients and 21 controls. We measured thrombin generation (TG) in WB and platelet poor plasma (PPP) of MM patients and controls.

Results

In WB-TG, we observed that the median time to the thrombin Peak was 52% longer in MM patients than in controls, while the median endoge

SUBMITTER: Li L 

PROVIDER: S-EPMC9271700 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature