Association Between GSDMB Gene Polymorphism and Cervical Cancer in the Northeast Chinese Han Population.

ABSTRACT: Objective: The purpose of this study was to investigate the relationship between GSDMB gene polymorphism and genetic susceptibility to cervical cancer in the Han population in Northeast China. Methods: In this case-control study, the genotypes and alleles of rs8067378 in the GSDMB gene were analyzed by multiplex polymerase chain reaction (PCR) and next-generation sequencing methods in 482 cervical cancer (CC) patients, 775 cervical squamous intraepithelial lesion (SIL) patients, and 495 healthy women. The potential relationships between the SNP of the GSDMB gene with SIL and CC were analyzed by multivariate logistic regression analysis combined with 10,000 permutation tests. Results: In the comparison between the SIL group and the control group, th

SUBMITTER: Li S 

PROVIDER: S-EPMC9271821 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature