Concordant and Heterogeneity of Single-Cell Transcriptome in Cardiac Development of Human and Mouse.

ABSTRACT: Normal heart development is vital for maintaining its function, and the development process is involved in complex interactions between different cell lineages. How mammalian hearts develop differently is still not fully understood. In this study, we identified several major types of cardiac cells, including cardiomyocytes (CMs), fibroblasts (FBs), endothelial cells (ECs), ECs/FBs, epicardial cells (EPs), and immune cells (macrophage/monocyte cluster, MACs/MONOs), based on single-cell transcriptome data from embryonic hearts of both human and mouse. Then, species-shared and species-specific marker genes were determined in the same cell type between the two species, and the genes with consistent and different expression patterns were also selected by constructing the developmental trajector

SUBMITTER: Shang M 

PROVIDER: S-EPMC9271823 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature