High-Dimensional Immune Profiling by Mass Cytometry Revealed the Circulating Immune Cell Landscape in Patients With Intracranial Aneurysm.

ABSTRACT:

Background

Increasing evidence supports a critical role of chronic inflammation in intracranial aneurysm (IA). Understanding how the immunological alterations in IA provides opportunities for targeted treatment. However, there is a lack of comprehensive and detailed characterization of the changes in circulating immune cells in IA.

Objective

To perform a comprehensive and detailed characterization of the changes in circulating immune cells in patients with IA.

Methods

Peripheral blood mononuclear cell samples from IA patients (n = 26) and age-and sex-matched healthy controls (HCs, n = 20) were analyzed using high dimensional mass cytometry, and the frequency and phenotype of immune cell subtypes were assessed.

Results

We identified 28 cell clusters and found th

SUBMITTER: Ge P 

PROVIDER: S-EPMC9271834 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature