Functional Variants Associated With CMPK2 and in ASB16 Influence Bovine Digital Dermatitis.

ABSTRACT: Bovine digital dermatitis (BDD) is an infectious disease of the hoof in cattle with multifactorial etiology and a polygenic influence on susceptibility. With our study, we identified genomic regions with the impact on occurrence and development of BDD. We used 5,040 genotyped animals with phenotype information based on the M-stage system for genome-wide association. Significant associations for single-nucleotide polymorphisms were found near genes CMPK2 (chromosome 11) and ASB16 (chromosome 19) both being implicated in immunological processes. A sequence analysis of the chromosomal regions revealed rs208894039 and rs109521151 polymorphisms as having significant influence on susceptibility to the disease. Specific genotypes were significantly more likely to be affected by BDD

SUBMITTER: Oelschlaegel D 

PROVIDER: S-EPMC9271848 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature