Proteomic and Functional Analysis of the Effects of Quinoxaline Derivatives on Entamoeba histolytica.

ABSTRACT: Quinoxalines are heterocyclic compounds that contain a benzene ring and a pyrazine ring. The oxidation of both nitrogen of the pyrazine ring results in quinoxaline derivatives (QdNO), which exhibit a variety of biological properties, including antiparasitic activity. However, its activity against Entamoeba histolytica, the protozoan that causes human amebiasis, is poorly understood. Recently, our group reported that various QdNOs produce morphological changes in E. histolytica trophozoites, increase reactive oxygen species, and inhibit thioredoxin reductase activity. Notably, T-001 and T-017 derivatives were among the QdNOs with the best activity. In order to contribute to the characterization of the antiamebic effect of QdNOs, in this work we analyzed the proteomic profile o

SUBMITTER: Avila-Bonilla RG 

PROVIDER: S-EPMC9271875 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature