Evaluation of Association Studies and Meta-Analyses of eNOS Polymorphisms in Type 2 Diabetes Mellitus Risk.

ABSTRACT: Background: Numerous studies reported the associations between endothelial nitric oxide synthase (eNOS) polymorphisms (4b/a VNTR (rs869109213), G894T (rs1799983) and T786C (rs2070744)) and type 2 diabetes mellitus (T2DM) risk. However, the conclusions were incongruent. Moreover, since no published meta-analyses were performed, a key issue regarding false-positive results needs to be addressed. Furthermore, four new articles have been published on these issues. Therefore, an updated meta-analysis was conducted to further explore these associations. Objectives: To investigate the association between eNOS 4b/a, G894T and T786C polymorphisms and T2DM risk. Methods: Studies were searched by using the PubMed, China National Knowledge Infrastructure (CNKI), Medl

SUBMITTER: Wang D 

PROVIDER: S-EPMC9271911 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature