A Highly Sensitive and Selective Fluorescein-Based Cu²⁺ Probe and Its Bioimaging in Cell.

ABSTRACT: Copper is a vital trace metal in human body, which plays the significant roles in amounts of physiological and pathological processes. The application of copper-selective probe has attracted great interests from environmental tests to life process research, yet a few of sensitive Cu²⁺ tests based on on-site analysis have been reported. In this paper, a novel fluorescein-based fluorescent probe N4 was designed, synthesized, and characterized, which exhibited high selectivity and sensitivity to Cu²⁺ comparing with other metal ions in ethanol-water (1/1, v/v) solution. The probe N4 bonded with Cu²⁺ to facilitate the ring-opening, and an obvious new band at 525 nm in the fluorescence spectroscopy appeared, which could be used for naked-eye detection of Cu²

SUBMITTER: Leng X 

PROVIDER: S-EPMC9271948 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature