Parkinsonian Syndromes in Motor Neuron Disease: A Clinical Study.

ABSTRACT:

Background

Parkinsonian syndromes may rarely occur in motor neuron disease (MND). However, previous studies are heterogeneous and mostly case reports or small case series. Therefore, we aimed to identify and characterize patients with concurrent parkinsonian syndromes extracted from a cohort of 1,042 consecutive cases diagnosed with MND at a tertiary Italian Center.

Methods

Diagnosis of Parkinson's disease (PD), progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) was made according to current criteria. Clinical characterization included: upper and lower motor neuron disease features, typical and atypical parkinsonian features, oculomotor disorders, cognitive testing, MRI features, and, when available molecular neuroimaging. Genetic testing was carried out fo

SUBMITTER: Pasquini J 

PROVIDER: S-EPMC9271964 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature