Dataset Information

Decreased peak expiratory flow rate associated with mortality in idiopathic pulmonary fibrosis: A preliminary report.

ABSTRACT:

Objectives

The peak expiratory flow rate (PEFR) is known to decrease in patients with sarcopenia. However, little is known about the clinical impact of the PEFR in idiopathic pulmonary fibrosis (IPF). This study aimed to confirm whether a decrease in PEFR over 6 months was associated with survival in IPF patients.

Methods

Consecutive IPF patients who had been assessed at a single center were retrospectively analyzed. The relative decline in PEFR over 6 months was assessed. Survival analyses were performed by univariate and multivariate Cox proportional hazard models.

Results

A total of 61 eligible cases (average age 70 years) were examined, and 21 patients (34.4%) died. The univariate Cox regression analysis showed that the body mass index, baseline % predicted forced vital capacity (FVC), baseline % predicted PEFR, % predicted diffusion capacity for carbon monoxide (DL_CO), relative decline in FVC, and relative decline in PEFR were prognostic factors. On multivariate analyses, relative decline in PEFR (hazard ratio [HR] 1.037, p < .05) and baseline % predicted FVC (HR 0.932, p < .001) were independent prognostic factors, whereas relative decline in FVC was not.

Conclusion

A decrease in PEFR after 6 months may predict worse survival in patients with IPF.

SUBMITTER: Fujita K

PROVIDER: S-EPMC9272050 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature

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Publications

Decreased peak expiratory flow rate associated with mortality in idiopathic pulmonary fibrosis: A preliminary report.

Fujita Kohei K Ohkubo Hirotsugu H Nakano Akiko A Takeda Norihisa N Fukumitsu Kensuke K Fukuda Satoshi S Kanemitsu Yoshihiro Y Uemura Takehiro T Tajiri Tomoko T Maeno Ken K Ito Yutaka Y Oguri Tetsuya T Ozawa Yoshiyuki Y Murase Takayuki T Niimi Akio A

Chronic respiratory disease 20220101

<h4>Objectives</h4>The peak expiratory flow rate (PEFR) is known to decrease in patients with sarcopenia. However, little is known about the clinical impact of the PEFR in idiopathic pulmonary fibrosis (IPF). This study aimed to confirm whether a decrease in PEFR over 6 months was associated with survival in IPF patients.<h4>Methods</h4>Consecutive IPF patients who had been assessed at a single center were retrospectively analyzed. The relative decline in PEFR over 6 months was assessed. Surviva ...[more]

PMID: 35792724

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Project description:BackgroundDaily evaluation of peak expiratory flow rate (PEFR) is quite useful for monitoring and adjusting an asthmatic patient's treatment. Many factors including geography, ethnicity, socio-economic conditions, gender, and anthropometric play a role in lung function differences studies have found. The aim of this study is to present normal PEFR and to establish a PEFR equation for Thai children living in a suburban environment.MethodsThis study includes a cross-section of healthy children aged 6 to 18. It was conducted in Phitsanulok Province in the lower north of Thailand. The children were chosen to participate from five primary and secondary schools over the period from February 2014 to January 2015. The children were instructed on how to use the Wright peak flow meter (Clement Clarke International Ltd.). All of the participants performed PEFR 3 times and the highest value was recorded.ResultsA total of 2,000 students were initially examined; 80 students were excluded from the study. A total of 1,920 healthy children were recruited between the ages of 6 and18 years. Among them, 719 (37.4%) were males and 1,201 (62.6%) were females. The median age was 18 [12-18] years old, mean height, weight, body mass index (BMI) and PEFR were 155.98±14.99 cm, 51.38±16.95 kg, 20.62±4.79 kg/m2 and 339.31±113.55 L/min, respectively. PEFR has a linear relationship in regards age, weight, height and BMI. For males, age was the strongest factor associated with PEFR (r=0.838, P<0.001). Females had a highly significant correlation between height and PEFR (r=0.532, P<0.001). The regression equations are PEFR = (1.34 × height) + (1.41 × weight) + (16.56 × age) - 137.88 for males (R2=0.751, P<0.001) and PEFR = (1.31 × height) + (0.94 × weight) + (7.30 × age) - 55.27 for females (R2=0.507, P<0.001).ConclusionsThis research study has provided the normal range of PEFR for Thai children aged from 6 to 18 years in Phitsanulok. The data was obtained using the Wright peak flow meter. Height, weight, and age were the significant determiners of the PEFR for each sex in the regression equation.

Dataset Information

Decreased peak expiratory flow rate associated with mortality in idiopathic pulmonary fibrosis: A preliminary report.

Objectives

Methods

Results

Conclusion

Publications

Decreased peak expiratory flow rate associated with mortality in idiopathic pulmonary fibrosis: A preliminary report.

Similar Datasets

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