Structural integrity of the anterior mid-cingulate cortex contributes to resilience to delirium in SuperAging.

ABSTRACT: Despite its devastating clinical and societal impact, approaches to treat delirium in older adults remain elusive, making it important to identify factors that may confer resilience to this syndrome. Here, we investigated a cohort of 93 cognitively normal older patients undergoing elective surgery recruited as part of the Successful Aging after Elective Surgery study. Each participant was classified either as a SuperAger (n = 19) or typically aging older adult (n = 74) based on neuropsychological criteria, where the former was defined as those older adults whose memory function rivals that of young adults. We compared these subgroups to examine the role of preoperative memory function in the incidence and severity of postoperative delirium. We additionally investigated the as

SUBMITTER: Katsumi Y 

PROVIDER: S-EPMC9272062 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature