ORIGINS OF THE OPIOID CRISIS AND ITS ENDURING IMPACTS.

ABSTRACT: Overdose deaths involving opioids have increased dramatically since the 1990s, leading to the worst drug overdose epidemic in U.S. history, but there is limited empirical evidence about the initial causes. In this article, we examine the role of the 1996 introduction and marketing of OxyContin as a potential leading cause of the opioid crisis. We leverage cross-state variation in exposure to OxyContin's introduction due to a state policy that substantially limited the drug's early entry and marketing in select states. Recently unsealed court documents involving Purdue Pharma show that state-based triplicate prescription programs posed a major obstacle to sales of OxyContin and suggest that less marketing was targeted to states with these programs. We find that OxyContin distribution was mo

SUBMITTER: Alpert A 

PROVIDER: S-EPMC9272388 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature