Pro-inflammatory polarization primes Macrophages to transition into a distinct M2-like phenotype in response to IL-4.

ABSTRACT: Tissue repair is largely regulated by diverse Mϕ populations whose functions are timing- and context-dependent. The early phase of healing is dominated by pro-inflammatory Mϕs, also known as M1, followed by the emergence of a distinct and diverse population that is collectively referred to as M2. The extent of the diversity of the M2 population is unknown. M2 Mϕs may originate directly from circulating monocytes or from phenotypic switching of pre-existing M1 Mϕs within the site of injury. The differences between these groups are poorly understood, but have major implications for understanding and treating pathologies characterized by deficient M2 activation, such as chronic wounds, which also exhibit diminished M1 Mϕ behavior. This study investigated the influence of prior M1 activation o

SUBMITTER: O'Brien EM 

PROVIDER: S-EPMC9272532 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature