Vascular Interventional Radiology-Guided Photothermal Therapy of Colorectal Cancer Liver Metastasis with Theranostic Gold Nanorods.

ABSTRACT: We report sub-100 nm optical/magnetic resonance (MR)/X-ray contrast-bearing theranostic nanoparticles (TNPs) for interventional image-guided photothermal therapy (PTT) of solid tumors. TNPs were composed of Au@Gd₂O₃:Ln (Ln = Yb/Er) with X-ray contrast (∼486 HU; 10¹⁴ NPs/mL, 0.167 nM) and MR contrast (∼1.1 × 10⁸ mM^-1 S^-1 at 9.4 T field strength). Although TNPs are deposited in tumors following systemic administration via enhanced permeation and retention effect, the delivered dose to tumors is typically low; this can adversely impact the efficacy of PTT. To overcome this limitation, we investigated the feasibility of site-selective hepatic image-guided delivery of TNPs in rats bearing colorectal liver metastasis (CRLM). The m

SUBMITTER: Parchur AK 

PROVIDER: S-EPMC9272590 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature