A natural mutator allele shapes mutation spectrum variation in mice.

ABSTRACT: Although germline mutation rates and spectra can vary within and between species, common genetic modifiers of the mutation rate have not been identified in nature¹. Here we searched for loci that influence germline mutagenesis using a uniquely powerful resource: a panel of recombinant inbred mouse lines known as the BXD, descended from the laboratory strains C57BL/6J (B haplotype) and DBA/2J (D haplotype). Each BXD lineage has been maintained by brother-sister mating in the near absence of natural selection, accumulating de novo mutations for up to 50 years on a known genetic background that is a unique linear mosaic of B and D haplotypes². We show that mice inheriting D haplotypes at a quantitative trait locus on chromosome 4 accumulate C>A germline mutations at a 50

SUBMITTER: Sasani TA 

PROVIDER: S-EPMC9272728 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature