Metapone: a Bioconductor package for joint pathway testing for untargeted metabolomics data.

ABSTRACT:

Motivation

Testing for pathway enrichment is an important aspect in the analysis of untargeted metabolomics data. Due to the unique characteristics of untargeted metabolomics data, some key issues have not been fully addressed in existing pathway testing algorithms: (i) matching uncertainty between data features and metabolites; (ii) lacking of method to analyze positive mode and negative mode liquid chromatography-mass spectrometry (LC/MS) data simultaneously on the same set of subjects; (iii) the incompleteness of pathways in individual software packages.

Results

We developed an innovative R/Bioconductor package: metabolic pathway testing with positive and negative mode data (metapone), which can perform two novel statistical tests that take matching uncertainty into consi

SUBMITTER: Tian L 

PROVIDER: S-EPMC9272804 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature