Impact of Isolyte Versus 0.9% Saline on Postoperative Event of Acute Kidney Injury Assayed by Urinary [TIMP-2] × [IGFBP7] in Patients Undergoing Cardiac Surgery.

ABSTRACT:

Objective

Administration of excess chloride in 0.9% normal saline (NS) decreases renal perfusion and glomerular filtration rate, thereby increasing the risk for acute kidney injury (AKI). In this study, the effect of NS versus Isolyte use during cardiac surgery on urinary levels of tissue inhibitor of metalloproteinase 2 and insulin-like growth factor-binding protein 7 [TIMP-2] × [IGFBP7] and postoperative risk of AKI were examined.

Design

Prospective, randomized, and single-blinded trial.

Setting

Single university medical center.

Participants

Thirty patients over 18 years without chronic renal insufficiency or recent AKI undergoing elective cardiac surgery.

Interventions

Subjects were randomized to receive either NS or Isolyte during the intraoperative

SUBMITTER: Lee NM 

PROVIDER: S-EPMC9272898 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature