Neural regeneration therapy after spinal cord injury induces unique brain functional reorganizations in rhesus monkeys.

ABSTRACT:

Purpose

Spinal cord injury (SCI) destroys the sensorimotor pathway and induces brain plasticity. However, the effect of treatment-induced spinal cord tissue regeneration on brain functional reorganization remains unclear. This study was designed to investigate the large-scale functional interactions in the brains of adult female Rhesus monkeys with injured and regenerated thoracic spinal cord.

Materials and methods

Resting-state functional magnetic resonance imaging (fMRI) combined with Granger Causality analysis (GCA) and motor behaviour analysis were used to assess the causal interaction between sensorimotor cortices, and calculate the relationship between causal interaction and hindlimb stepping in nine Rhesus monkeys undergoing lesion-induced spontaneous recovery (injure

SUBMITTER: Rao JS 

PROVIDER: S-EPMC9272921 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature