Age-associated changes to neuronal dynamics involve a disruption of excitatory/inhibitory balance in C. elegans.

ABSTRACT: In the aging brain, many of the alterations underlying cognitive and behavioral decline remain opaque. Caenorhabditis elegans offers a powerful model for aging research, with a simple, well-studied nervous system to further our understanding of the cellular modifications and functional alterations accompanying senescence. We perform multi-neuronal functional imaging across the aged C. elegans nervous system, measuring an age-associated breakdown in system-wide functional organization. At single-cell resolution, we detect shifts in activity dynamics toward higher frequencies. In addition, we measure a specific loss of inhibitory signaling that occurs early in the aging process and alters the systems' critical excitatory/inhibitory balance. These effects are recapitulated with

SUBMITTER: Wirak GS 

PROVIDER: S-EPMC9273219 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature