Computational Insights into the Structural and Functional Impacts of nsSNPs of Bone Morphogenetic Proteins.

ABSTRACT: BMPs (bone morphogenetic proteins) are multipurpose (transforming growth factor)TGF-superfamily released cytokines. These glycoproteins, acting as disulfide-linked homo- or heterodimers, are highly potent regulators of bone and cartilage production and repair, cell proliferation throughout embryonic development, and bone homeostasis in the adults. Due to the fact that genetic variation might influence structural functions, this study is aimed to determine the pathogenic effect of nonsynonymous single-nucleotide polymorphisms (nsSNPs) in BMP genes. The implications of these variations, investigated using computational analysis and molecular models of the mature TGF-β domain, revealed the impact of modifications on the function of BMP protein. The three-dimensional (3D) structure anal

SUBMITTER: Ahmad HI 

PROVIDER: S-EPMC9273450 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature