Directly immersible silicon photonic probes: Application to rapid SARS-CoV-2 serological testing.

ABSTRACT: Silicon photonic probes based on broad-band Mach-Zehnder interferometry are explored for the first time as directly immersible immunosensors alleviating the need for microfluidics and pumps. Each probe includes two U-shaped waveguides allowing light in- and out-coupling from the same chip side through a bifurcated fiber and a mechanical coupler. At the opposite chip side, two Mach-Zehnder interferometers (MZI) are located enabling real-time monitoring of binding reactions by immersion of this chip side into a sample. The sensing arm windows of the two MZIs have different length resulting in two distinct peaks in the Fourier domain, the phase shift of which can be monitored independently through Fast Fourier Transform of the output spectrum. The photonic probes analytical potential was demo

SUBMITTER: Angelopoulou M 

PROVIDER: S-EPMC9273522 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature