Genomic and transcriptomic analysis of Korean colorectal cancer patients.

ABSTRACT:

Background

Colorectal cancer (CRC) is the third most common type of diagnosed cancer in the world and has the second-highest mortality rate. Meanwhile, South Korea has the second-highest incidence rate for CRC in the world.

Objective

To assess the possible influence of ethnicity on the molecular profile of colorectal cancer, we compared genomic and transcriptomic features of South Korean CRCs with European CRCs.

Methods

We assembled a genomic and transcriptomic dataset of South Korean CRC patients (KOCRC; n = 126) from previous studies and European cases (EUCRC; n = 245) selected from The Cancer Genome Atlas (TCGA). Then, we compared the two datasets in terms of clinical data, driver genes, mutational signature, gene sets, consensus molecular subtype, and fusion genes

SUBMITTER: Jeon SA 

PROVIDER: S-EPMC9273532 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature