Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications.

ABSTRACT: Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known about its aetiology, risk factors, and disease progression. There are currently neither validated biomarkers for diagnostic screening nor specific medication for autism. Over the last two decades, there have been remarkable advances in genetics, with hundreds of genes identified and validated as being associated with a high risk for autism. The convergence of neuroscience methods is becoming more widely recognized for its significance in elucidating the pathological mechanisms of autism. Efforts have been devoted to exploring the behavioural functions, key pathological mechanisms and potential treatments of aut

SUBMITTER: Jiang CC 

PROVIDER: S-EPMC9273593 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature