Elevated Basal Serum Tryptase: Disease Distribution and Variability in a Regional Health System.

ABSTRACT:

Background

Hereditary-alpha tryptasemia (HαT) is the most common etiology for elevated basal serum tryptase (BST). However, the utility of tryptase genotyping of individuals with elevated BST in general clinical practice remains undefined. Moreover, studies showing associations between elevated BST and chronic kidney disease (CKD), myelodysplastic syndrome (MDS), rheumatoid arthritis, or eosinophilic esophagitis did not include tryptase genotyping.

Objective

To determine the utility of tryptase genotyping among individuals with moderate elevations in BST at a regional health system.

Methods

Clinical and laboratory data from 109 subjects with basal tryptase values of 7.5 ng/mL or greater who were tested for HαT or had a disorder previously linked to elevated BST were c

SUBMITTER: Waters AM 

PROVIDER: S-EPMC9273808 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature