Clinical and Biological Aspects of Disseminated Tumor Cells and Dormancy in Breast Cancer.

ABSTRACT: Progress in detection and treatment have drastically improved survival for early breast cancer patients. However, distant recurrence causes high mortality and is typically considered incurable. Cancer dissemination occurs via circulating tumor cells (CTCs) and up to 75% of breast cancer patients could harbor micrometastatses at time of diagnosis, while metastatic recurrence often occurs years to decades after treatment. During clinical latency, disseminated tumor cells (DTCs) can enter a state of cell cycle arrest or dormancy at distant sites, and are likely shielded from immune detection and treatment. While this is a challenge, it can also be seen as an outstanding opportunity to target dormant DTCs on time, before their transformation into lethal macrometastatic lesions. Here, we

SUBMITTER: Ring A 

PROVIDER: S-EPMC9274007 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature