Prenatal Exposure to Ambient Air Pollution and Epigenetic Aging at Birth in Newborns

ABSTRACT: In utero air pollution exposure has been associated with adverse birth outcomes, yet effects of air pollutants on regulatory mechanisms in fetal growth and critical windows of vulnerability during pregnancy are not well understood. There is evidence that epigenetic alterations may contribute to these effects. DNA methylation (DNAm) based age estimators have been developed and studied extensively with health outcomes in recent years. Growing literature suggests environmental factors, such as air pollution and smoking, can influence epigenetic aging. However, little is known about the effect of prenatal air pollution exposure on epigenetic aging. In this study, we leveraged existing data on prenatal air pollution exposure and cord blood DNAm from 332 mother-child pairs in the Early Autism Ri

SUBMITTER: Song A 

PROVIDER: S-EPMC9274082 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature