Cancer Risk and Mutational Patterns Following Organ Transplantation.

ABSTRACT: The rapid development of medical technology and widespread application of immunosuppressive drugs have improved the success rate of organ transplantation significantly. However, the use of immunosuppressive agents increases the frequency of malignancy greatly. With the prospect of "precision medicine" for tumors and development of next-generation sequencing technology, more attention has been paid to the application of high-throughput sequencing technology in clinical oncology research, which is mainly applied to the early diagnosis of tumors and analysis of tumor-related genes. All generations of cancers carry somatic mutations, meanwhile, significant differences were observed in mutational signatures across tumors. Systematic sequencing of cancer genomes from patients after organ transpl

SUBMITTER: Shen Y 

PROVIDER: S-EPMC9274140 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature