Association of CD90 Expression by CD14⁺ Dendritic-Shaped Cells in Rheumatoid Arthritis Synovial Tissue With Chronic Inflammation.

ABSTRACT:

Objective

CD14⁺ dendritic-shaped cells show a dendritic morphology under the electron microscopy and engage in a pseudoemperipolesis phenomenon with lymphocytes. CD90 has been used as a marker of a major subset of fibroblast-like synoviocytes in rheumatoid arthritis (RA). In this study, we investigated the significance of CD90 expression in CD14⁺ dendritic-shaped cells and its correlation with RA chronic inflammation.

Methods

Double immunofluorescence staining for CD14 and CD90 was performed in the collected tissues, including 12 active RA synovial tissues. The localization of CD14⁺ CD90⁺ cells, the percentages of CD14⁺ CD90⁺ cells and vascular areas, the degree of synovitis, and clinical data were investigate

SUBMITTER: Kurose R 

PROVIDER: S-EPMC9274357 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature