Inflammatory biomarkers, multi-morbidity, and biologic aging.

ABSTRACT:

Objectives

To study the association between multi-morbidity percentiles, which is a measure of clinical aging, and interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-α.

Methods

Participants 50 to 95 years of age from the Mayo Clinic Study of Aging were assigned age- and sex-specific multi-morbidity percentiles using look-up tables that were reported previously (n = 1646). Percentiles were divided into quintiles for analysis. Plasma IL-6, IL-10, and TNF-α levels were measured in 1595 participants. Median inflammatory marker levels were compared across multi-morbidity quintiles using nonparametric tests.

Results

People with higher multi-morbidity percentiles had significantly higher IL-6 and TNF-α levels compared with those with lower multi-morbidity percentiles

SUBMITTER: St Sauver J 

PROVIDER: S-EPMC9274410 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature