Association between the loudness dependence of auditory evoked potentials and age in patients with schizophrenia and depression.

ABSTRACT:

Objective

Although serotonergic dysfunction is significantly associated with major depressive disorder (MDD) and schizophrenia (SCZ), comparison of serotonergic dysfunction in both diseases has received little attention. Serotonin hypotheses have suggested diminished and elevated serotonin activity in MDD and SCZ, respectively. However, the foundations underlying these hypotheses are unclear regarding changes in serotonin neurotransmission in the aging brain. The loudness dependence of auditory evoked potentials (LDAEP) reflects serotonin neurotransmission. The present study compared the LDAEP between patients with SCZ or MDD and healthy controls (HCs). We further examined whether age was correlated with the LDAEP and clinical symptoms.

Methods

This prospective clinical stud

SUBMITTER: Jang KI 

PROVIDER: S-EPMC9274422 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature