Significance of circRNAs as biomarkers for systemic lupus erythematosus: a systematic review and meta-analysis.

ABSTRACT:

Objective

To comprehensively evaluate the significance of circular RNAs (circRNAs) as potential diagnostic biomarkers for systemic lupus erythematosus (SLE) via pooled analyses of data from published studies that focussed on the association between circRNAs and SLE.

Methods

The systematic review and meta-analysis protocol was registered in PROSPERO (registration No. CRD42021229383). Relevant studies published before 3 April 2022 were selected to verify the relationship between circRNA expression levels and SLE. Extracted data were analysed using a random-effects model with Meta-DiSc 1.4 and Stata 16 software. Transcription factors related to hsa_circ_0000479 and its parental gene were extracted from the TRCirc and hTFtarget databases, respectively.

Results

A total of

SUBMITTER: Wang L 

PROVIDER: S-EPMC9274425 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature