Purpurin suppresses atopic dermatitis via TNF-α/IFN-γ-induced inflammation in HaCaT cells.

ABSTRACT:

Objective

We investigated whether purpurin inhibits various pathways of inflammation leading to atopic dermatitis.

Introduction

1,2,4-Trihydroxyanthraquinone, commonly called purpurin, is an anthraquinone that is a naturally occurring red/yellow dye. Purpurin is a highly antioxidative anthraquinone and previous studies have reported antibacterial, anti-tumor, and anti-oxidation activities in cells and animals. However, the skin inflammatory inhibition activity mechanism study of purpurin has not been elucidated in vitro.

Methods

In this study, we investigated the anti-inflammatory activity of purpurin in HaCaT (human keratinocyte) cell lines stimulated with a mixture of tumor necrosis factor-alpha (TNF-α)/Interferon-gamma (IFN-γ). The inhibitory effect of Purpurin on

SUBMITTER: Oh JH 

PROVIDER: S-EPMC9274433 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature