Integrating Au and ZnO nanoparticles onto graphene nanosheet for enhanced sonodynamic therapy.

ABSTRACT: Sonodynamic therapy has attracted widespread attention for cancer treatment because of its noninvasiveness and high tissue-penetration ability. Generally, ultrasound irradiation of sonosensitizers produces separated electrons (e^-) and holes (h⁺), which inhibits cancer by producing reactive oxygen species (ROS). However, the separated electrons (e^-) and holes (h⁺) could easily recombine, lowering the yield of ROS and hindering the application of sonodynamic therapy (SDT). Herein, we present a highly efficient sonosensitizer system for enhanced sonodynamic therapy built on reduced graphene oxide (rGO) nanosheets, bridged ZnO and Au nanoparticles, coated with polyvinyl pyrrolidone (PVP). The ultrasound irradiation activates ZnO nanoparticles to gene

SUBMITTER: Wang F 

PROVIDER: S-EPMC9274620 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature