Gene Therapy in Orthopaedics: Progress and Challenges in Pre-Clinical Development and Translation.

ABSTRACT: In orthopaedics, gene-based treatment approaches are being investigated for an array of common -yet medically challenging- pathologic conditions of the skeletal connective tissues and structures (bone, cartilage, ligament, tendon, joints, intervertebral discs etc.). As the skeletal system protects the vital organs and provides weight-bearing structural support, the various tissues are principally composed of dense extracellular matrix (ECM), often with minimal cellularity and vasculature. Due to their functional roles, composition, and distribution throughout the body the skeletal tissues are prone to traumatic injury, and/or structural failure from chronic inflammation and matrix degradation. Due to a mixture of environment and endogenous factors repair processes are often slow and fail t

SUBMITTER: Watson-Levings RS 

PROVIDER: S-EPMC9274665 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature