Dataset Information

Tumor microenvironment-activated single-atom platinum nanozyme with H₂O₂ self-supplement and O₂-evolving for tumor-specific cascade catalysis chemodynamic and chemoradiotherapy.

ABSTRACT: Nanozyme-based tumor collaborative catalytic therapy has attracted a great deal of attention in recent years. However, their cooperative outcome remains a great challenge due to the unique characteristics of tumor microenvironment (TME), such as insufficient endogenous hydrogen peroxide (H₂O₂) level, hypoxia, and overexpressed intracellular glutathione (GSH). Methods: Herein, a TME-activated atomic-level engineered PtN₄C single-atom nanozyme (PtN₄C-SAzyme) is fabricated to induce the "butterfly effect" of reactive oxygen species (ROS) through facilitating intracellular H₂O₂ cycle accumulation and GSH deprivation as well as X-ray deposition for ROS-involving CDT and O₂-dependent chemoradiotherapy. Results

SUBMITTER: Xu Q

PROVIDER: S-EPMC9274735 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

ACCESS DATA

Dataset Information

Tumor microenvironment-activated single-atom platinum nanozyme with H₂O₂ self-supplement and O₂-evolving for tumor-specific cascade catalysis chemodynamic and chemoradiotherapy.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Tumor microenvironment-activated single-atom platinum nanozyme with H2O2 self-supplement and O2-evolving for tumor-specific cascade catalysis chemodynamic and chemoradiotherapy.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Tumor microenvironment-activated single-atom platinum nanozyme with H₂O₂ self-supplement and O₂-evolving for tumor-specific cascade catalysis chemodynamic and chemoradiotherapy.