Extracellular vesicles as bioactive nanotherapeutics: An emerging paradigm for regenerative medicine.

ABSTRACT: In recent decades, extracellular vesicles (EVs), as bioactive cell-secreted nanoparticles which are involved in various physiological and pathological processes including cell proliferation, immune regulation, angiogenesis and tissue repair, have emerged as one of the most attractive nanotherapeutics for regenerative medicine. Herein we provide a systematic review of the latest progress of EVs for regenerative applications. Firstly, we will briefly introduce the biogenesis, function and isolation technology of EVs. Then, the underlying therapeutic mechanisms of the native unmodified EVs and engineering strategies of the modified EVs as regenerative entities will be discussed. Subsequently, the main focus will be placed on the tissue repair and regeneration applications of EVs on various or

SUBMITTER: Li M 

PROVIDER: S-EPMC9274746 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature