Upregulated lncRNA‐NEF predicts recurrence and poor treatment outcomes of ankylosing spondylitis

ABSTRACT: Abstract

Introduction

Osteoporosis is related to lncRNA‐neighboring enhancer of FOXA2 (NEF) and inversely correlated to ankylosing spondylitis (AS), implying that lncRNA‐NEF might also relate to AS. Thus, the study was carried out to investigate the involvement of lncRNA‐NEF in AS.

Methods

The study included 60 AS patients and 60 healthy controls. LncRNA‐NEF expression in synovial fluid samples was analyzed by reverse transcription quantitative real‐time polymerase chain reaction. Disease activity of the 60 AS patients was determined using the Ankylosing Spondylitis Disease Activity Score (ASDAS) 1–4 and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Western blot was carried out to investigate the effects of lncRNA‐NEF on inflammatory factors in human fibrob

SUBMITTER: Han D 

PROVIDER: S-EPMC9274798 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature