Effect of Phentermine on Hepatic Steatosis in Bariatric Surgery: A Pilot Study.

ABSTRACT:

Objective

Hepatic steatosis is associated with increased surgical complications in bariatric surgery patients. We aimed to evaluate the effect of phentermine in reducing hepatic steatosis, adipose tissue, and surgical complications in patients undergoing bariatric surgery.

Methods

This was a two-arm, double-blind, randomized, controlled pilot trial of 64 adult subjects with BMI >35 kg/m2 selected for bariatric surgery randomized into phentermine group (15 mg once daily) or placebo group for 8 weeks. Both groups adhered to a hypocaloric diet (500 calories/day) and an individualized exercise program. The primary endpoint was reducing the frequency of hepatic steatosis measured by ultrasound and reducing adipose tissue through fat mass in total kilograms or percentage. Key seco

SUBMITTER: Perez-Cruz E 

PROVIDER: S-EPMC9275005 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature