New solid phase methodology for the synthesis of biscoumarin derivatives: experimental and in silico approaches.

ABSTRACT: The simple and greener one-pot approach for the synthesis of biscoumarin derivatives using catalytic amounts of nano-MoO₃ catalyst under mortar-pestle grinding was described. The use of non-toxic and mild catalyst, cost-effectiveness, ordinary grinding, and good to the excellent yield of the final product makes this procedure a more attractive pathway for the synthesis of biologically remarkable pharmacophores. Accordingly, biscoumarin derivatives were successfully extended in the developed protocols. Next, a computational investigation was performed to identify the potential biological targets of this set of compounds. In this case, first, a similarity search on different virtual libraries was performed to find an ideal biological target for these derivatives. Results showed th

SUBMITTER: Zarenezhad E 

PROVIDER: S-EPMC9275028 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature