Network analysis of synovial RNA sequencing identifies gene-gene interactions predictive of response in rheumatoid arthritis.

ABSTRACT:

Background

To determine whether gene-gene interaction network analysis of RNA sequencing (RNA-Seq) of synovial biopsies in early rheumatoid arthritis (RA) can inform our understanding of RA pathogenesis and yield improved treatment response prediction models.

Methods

We utilized four well curated pathway repositories obtaining 10,537 experimentally evaluated gene-gene interactions. We extracted specific gene-gene interaction networks in synovial RNA-Seq to characterize histologically defined pathotypes in early RA and leverage these synovial specific gene-gene networks to predict response to methotrexate-based disease-modifying anti-rheumatic drug (DMARD) therapy in the Pathobiology of Early Arthritis Cohort (PEAC). Differential interactions identified within each network we

SUBMITTER: Sciacca E 

PROVIDER: S-EPMC9275048 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature