Evaluation of NKp46 expression and cytokine production of decidual NK cells in women with recurrent pregnancy loss

ABSTRACT: Abstract

Purpose

NKp46, a receptor on NK cells, is involved in cytotoxicity and cytokine production. The authors aimed to evaluate the effect of NKp46 on decidual NK (dNK) cells during pregnancy and whether it can be a marker for immunological abnormalities in women with recurrent pregnancy loss (RPL).

Methods

Flow‐cytometric analysis was made to assess NKp46 expression and intracellular cytokine production of dNK cells. The proportion of NKp46+ dNK cells was analyzed among RPL patients who aborted karyotypically normal pregnancies and those who either aborted karyotypically abnormal pregnancies or without genetic studies, and controls who were going through the induced abortion.

Results

The %NKp46+ and %NKp46bright dNK cells were significantly lower in the RPL w

SUBMITTER: Yamamoto M 

PROVIDER: S-EPMC9275167 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature