Restrictive prescription of antibiotics in preterm infants with premature rupture of membranes.

ABSTRACT:

Background

In preterm infants with premature rupture of membranes, antibiotic treatment is frequently started but rates of early onset sepsis are lower. In line with national guidelines, a stratified approach in the decision to start antibiotic treatment using maternal history, clinical impression and biomarkers has been implemented in our level III neonatal center and its results are evaluated.

Methods

Retrospective cohort study of all preterm newborns with rupture of membranes at least 1 h prior to delivery admitted to our tertiary neonatal intensive care unit. Data on antibiotic exposure, mortality and major neonatal complications were extracted from the electronic patient charts to evaluate the effects and safety of our stratified approach.

Results

Four hundred fi

SUBMITTER: Armann J 

PROVIDER: S-EPMC9275236 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature