Multidomain trials to prevent dementia: addressing methodological challenges.

ABSTRACT:

Background

Multidomain trials to prevent dementia by simultaneously targeting multiple risk factors with non-pharmacological lifestyle interventions show promise. Designing trials to evaluate the efficacy of individual interventions and their combinations is methodologically challenging. Determining the efficacy is, nevertheless, important to individuals, payers, and for resource allocations to support intervention implementation.

Main body

The central rationale for seminal trials improving cardiovascular health or reducing falls risk in older adults is that multifactorial conditions may be amenable to improvement by simultaneously targeting multiple modifiable risk factors. Similar reasoning underlies lifestyle interventions to reduce dementia risk using combinations of phy

SUBMITTER: Montero-Odasso M 

PROVIDER: S-EPMC9275261 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature