Copy number variation at the 22q11.2 locus influences prevalence, severity, and psychiatric impact of sleep disturbance.

ABSTRACT:

Background

Sleep disturbance is common, impairing, and may affect symptomatology in developmental neuropsychiatric disorders. Here, we take a genetics-first approach to study the complex role of sleep in psychopathology. Specifically, we examine severity of sleep disturbance in individuals with a reciprocal copy number variant (CNV) at the 22q11.2 locus and determine sleep's effect on psychiatric symptoms. CNVs (deletion or duplication) at this locus confer some of the greatest known risks of neuropsychiatric disorders; recent studies suggest the 22q11.2 deletion negatively impacts sleep, but sleep disruption associated with 22q11.2 duplication has not been investigated.

Methods

We compared subjective sleep disturbance and its relationship to psychiatric symptoms cross-secti

SUBMITTER: O'Hora KP 

PROVIDER: S-EPMC9275284 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature