B value and first-order motion moment optimized data acquisition for repeatable quantitative intravoxel incoherent motion DWI.

ABSTRACT:

Purpose

To design a b value and first-order motion moment (M₁ ) optimized data acquisition for repeatable intravoxel incoherent motion (IVIM) quantification in the liver.

Methods

Cramer-Rao lower bound optimization was performed to determine optimal monopolar and optimal 2D samplings of the b-M₁ space based on noise performance. Monte Carlo simulations were used to evaluate the bias and variability in estimates obtained using the proposed optimal samplings and conventional monopolar sampling. Diffusion MRI of the liver was performed in 10 volunteers using 3 IVIM acquisitions: conventional monopolar, optimized monopolar, and b-M₁ -optimized gradient waveforms (designed based on the optimal 2D sampling). IVIM parameter maps of diffusion coeffic

SUBMITTER: Simchick G 

PROVIDER: S-EPMC9275352 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature