Ontology highlight
ABSTRACT:
SUBMITTER: Naser FJ
PROVIDER: S-EPMC9275394 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Naser Fuad J FJ Jackstadt Madelyn M MM Fowle-Grider Ronald R Spalding Jonathan L JL Cho Kevin K Stancliffe Ethan E Doonan Steven R SR Kramer Eva T ET Yao Lijun L Krasnick Bradley B Ding Li L Fields Ryan C RC Kaufman Charles K CK Shriver Leah P LP Johnson Stephen L SL Patti Gary J GJ
Cell metabolism 20210513 7
The cell-intrinsic nature of tumor metabolism has become increasingly well characterized. The impact that tumors have on systemic metabolism, however, has received less attention. Here, we used adult zebrafish harboring BRAF<sup>V600E</sup>-driven melanoma to study the effect of cancer on distant tissues. By applying metabolomics and isotope tracing, we found that melanoma consume ~15 times more glucose than other tissues measured. Despite this burden, circulating glucose levels were maintained ...[more]