Walking strides direct rapid and flexible recruitment of visual circuits for course control in Drosophila.

ABSTRACT: Flexible mapping between activity in sensory systems and movement parameters is a hallmark of motor control. This flexibility depends on the continuous comparison of short-term postural dynamics and the longer-term goals of an animal, thereby necessitating neural mechanisms that can operate across multiple timescales. To understand how such body-brain interactions emerge across timescales to control movement, we performed whole-cell patch recordings from visual neurons involved in course control in Drosophila. We show that the activity of leg mechanosensory cells, propagating via specific ascending neurons, is critical for stride-by-stride steering adjustments driven by the visual circuit, and, at longer timescales, it provides information about the moving body's state to flexibly recruit

SUBMITTER: Fujiwara T 

PROVIDER: S-EPMC9275417 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature